Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.V396Fs

c.1187delinsTGGGTGGAFs

Surrounding Variants

1 paper

NM_002880.4

p.L397L

c.1189C>T

2 papers

NM_002880.4

p.L397V

c.1189C>G

3 papers

NM_002880.4

p.L397M

c.1189C>A

1 paper

NM_002880.4

p.L397_R398insFs

c.1191_1192insG

2 papers

NM_002880.4

p.R398L

c.1193G>T

1 paper

NM_002880.4

p.N392H

c.1174A>C

3 papers

NM_002880.4

p.R391S

c.1173G>T

3 papers

NM_002880.4

p.R391S

c.1173G>C

18 papers

NM_002880.4

p.R391W

c.1171A>T

1 paper

NM_002880.4

p.F390delFs

c.1168_1169delAA

1 paper

NM_002880.4

p.A389V

c.1166C>T

1 paper

NM_002880.4

p.F387S

c.1160T>C