Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.W368*

c.1103G>A

Surrounding Variants

1 paper

NM_002880.4

p.W368*

c.1104G>A

1 paper

NM_002880.4

p.K367fs

c.1099_1100fs

1 paper

NM_002880.4

p.V363F

c.1087G>T

1 paper

NM_002880.4

p.T362A

c.1084A>G

24 papers

NM_002880.4

p.G361A

c.1082G>C

2 papers

NM_002880.4

p.G361E

c.1082G>A

2 papers

NM_002880.4

p.F360S

c.1079T>C

3 papers

NM_002880.4

p.S359A

c.1075T>G

1 paper

NM_002880.4

p.G358D

c.1073G>A

1 paper

NM_002880.4

p.S357A

c.1069T>G

1 paper

NM_002880.4

p.R354Q

c.1061G>A

1 paper

NM_002880.4

p.R354W

c.1060C>T