Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_002880.4

p.T260P

c.778A>C

Surrounding Variants

1 paper

NM_002880.4

p.T260S

c.778A>T

5 papers

NM_002880.4

p.T260I

c.779C>T

11 papers

NM_002880.4

p.T260R

c.779C>G

1 paper

NM_002880.4

p.T260K

c.779C>A

1 paper

NM_002880.4

p.S259delins

c.776_777delinsTA

44 papers

NM_002880.4

p.S259F

c.776C>T

9 papers

NM_002880.4

p.S259C

c.776C>G

4 papers

NM_002880.4

p.S259Y

c.776C>A

59 papers

NM_002880.4

p.S259A

c.775T>G

17 papers

NM_002880.4

p.S259P

c.775T>C

18 papers

NM_002880.4

p.S259T

c.775T>A

53 papers

NM_002880.4

p.P261S

c.781C>T