Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

228 papers

NM_002880.4

p.S257L

c.770C>T

Surrounding Variants

5 papers

NM_002880.4

p.S257W

c.770C>G

1 paper

NM_002880.4

p.S257A

c.769T>G

17 papers

NM_002880.4

p.S257P

c.769T>C

2 papers

NM_002880.4

p.S257T

c.769T>A

19 papers

NM_002880.4

p.R256S

c.768G>T

17 papers

NM_002880.4

p.R256S

c.768G>C

1 paper

NM_002880.4

p.R256T

c.767G>C

1 paper

NM_002880.4

p.R256K

c.767G>A

2 papers

NM_002880.4

p.R256G

c.766A>G

59 papers

NM_002880.4

p.S259A

c.775T>G

17 papers

NM_002880.4

p.S259P

c.775T>C

18 papers

NM_002880.4

p.S259T

c.775T>A