Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.S247P

c.739T>C

Surrounding Variants

1 paper

NM_002880.4

p.S247Y

c.740C>A

3 papers

NM_002880.4

p.E248K

c.742G>A

1 paper

NM_002880.4

p.P245S

c.733C>T

2 papers

NM_002880.4

p.S244C

c.730A>T

1 paper

NM_002880.4

p.S243C

c.728C>G

1 paper

NM_002880.4

p.L251V

c.751C>G

1 paper

NM_002880.4

p.L251P

c.752T>C

1 paper

NM_002880.4

p.S252C

c.755C>G

1 paper

NM_002880.4

p.N241T

c.722A>C

1 paper

NM_002880.4

p.Q253*

c.757C>T

1 paper

NM_002880.4

p.S252_Q253del1

c.756_758delTGG

3 papers

NM_002880.4

p.R254fs

c.760_761fs