Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.F238delFs

c.713delA

Surrounding Variants

1 paper

NM_002880.4

p.F238fs

c.712_713fs

5 papers

NM_002880.4

p.A237T

c.709G>A

1 paper

NM_002880.4

p.H236Q

c.708C>G

1 paper

NM_002880.4

p.H236Q

c.708C>A

1 paper

NM_002880.4

p.N241T

c.722A>C

2 papers

NM_002880.4

p.P235S

c.703C>T

1 paper

NM_002880.4

p.P235T

c.703C>A

1 paper

NM_002880.4

p.T234I

c.701C>T

1 paper

NM_002880.4

p.S243C

c.728C>G

2 papers

NM_002880.4

p.S244C

c.730A>T

1 paper

NM_002880.4

p.S233A

c.697T>G

1 paper

NM_002880.4

p.P245S

c.733C>T