Varaico: Literature-Extracted Genetic Variants

RAP1GAP

81 papers

RefSeq Summary

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound f...

Pfam Domains

GoLocoaa 1–17UCSCGoLoco motif

Rap-GAP_dimeraa 86–192UCSCRap/Ran-GAP protein dimerization domain

Rap_GAPaa 210–391UCSCRap/ran-GAP

Gene Aliases

HGNC Name

RAP1 GTPase activating protein

HGNC Previous Symbol

RAP1GA1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002885.4

p.T457P

c.1369A>C

Surrounding Variants

1 paper

NM_002885.4

p.G461R

c.1381G>C

1 paper

NM_002885.4

p.G461R

c.1381G>A

1 paper

NM_002885.4

p.K450N

c.1350G>T

1 paper

NM_002885.4

p.K450N

c.1350G>C

1 paper

NM_002885.4

p.A464P

c.1390G>C

1 paper

NM_002885.4

p.G446A

c.1337G>C

1 paper

NM_002885.4

p.G446E

c.1337G>A

1 paper

NM_002885.4

p.S441A

c.1321T>G

1 paper

NM_002885.4

p.R436W

c.1306C>T

1 paper

NM_002885.4

p.R433Q

c.1298G>A

1 paper

NM_002885.4

p.G425fs

c.1273_1274fs

1 paper

NM_002885.4

p.G425delFs

c.1274delC