Varaico: Literature-Extracted Genetic Variants

RASGRF2

88 papers

RefSeq Summary

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1,...

Pfam Domains

PHaa 23–133UCSCPH domain

RhoGEFaa 247–427UCSCRhoGEF domain

RasGEF_Naa 638–771UCSCRasGEF N-terminal motif

RasGEFaa 1005–1183UCSCRasGEF domain

Gene Aliases

HGNC Name

Ras protein specific guanine nucleotide releasing factor 2

HGNC Alias Symbols

GRF2; Ras-GRF2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006909.3

p.R165*

c.493C>T

Surrounding Variants

1 paper

NM_006909.3

p.Q171*

c.511C>T

1 paper

NM_006909.3

p.D172N

c.514G>A

1 paper

NM_006909.3

p.M144I

c.432G>A

1 paper

NM_006909.3

p.M144I

c.432G>C

1 paper

NM_006909.3

p.M144I

c.432G>T

1 paper

NM_006909.3

p.R191Q

c.572G>A

1 paper

NM_006909.3

p.D205G

c.614A>G

1 paper

NM_006909.3

p.G218G

c.654A>T

1 paper

NM_006909.3

p.V229M

c.685G>A

1 paper

NM_006909.3

p.R244I

c.731G>T

1 paper

NM_006909.3

p.Y258Y

c.774C>T

1 paper

NM_006909.3

p.R271Q

c.812G>A