Varaico: Literature-Extracted Genetic Variants

RASGRF2

88 papers

RefSeq Summary

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1,...

Pfam Domains

PHaa 23–133UCSCPH domain

RhoGEFaa 247–427UCSCRhoGEF domain

RasGEF_Naa 638–771UCSCRasGEF N-terminal motif

RasGEFaa 1005–1183UCSCRasGEF domain

Gene Aliases

HGNC Name

Ras protein specific guanine nucleotide releasing factor 2

HGNC Alias Symbols

GRF2; Ras-GRF2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006909.3

p.H404R

c.1211A>G

Surrounding Variants

1 paper

NM_006909.3

p.P389S

c.1165C>T

1 paper

NM_006909.3

p.T459M

c.1376C>T

1 paper

NM_006909.3

p.T459T

c.1377G>A

1 paper

NM_006909.3

p.R462H

c.1385G>A

1 paper

NM_006909.3

p.Q387H

c.1161G>C

1 paper

NM_006909.3

p.Q387H

c.1161G>T

1 paper

NM_006909.3

p.Q387*

c.1159C>T

1 paper

NM_006909.3

p.Q365R

c.1094A>G

1 paper

NM_006909.3

p.L350L

c.1050C>T

1 paper

NM_006909.3

p.F339V

c.1015T>G

1 paper

NM_006909.3

p.G309V

c.926G>T

1 paper

NM_006909.3

p.S465S

c.1395T>G