Varaico: Literature-Extracted Genetic Variants

RASGRF2

88 papers

RefSeq Summary

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1,...

Pfam Domains

PHaa 23–133UCSCPH domain

RhoGEFaa 247–427UCSCRhoGEF domain

RasGEF_Naa 638–771UCSCRasGEF N-terminal motif

RasGEFaa 1005–1183UCSCRasGEF domain

Gene Aliases

HGNC Name

Ras protein specific guanine nucleotide releasing factor 2

HGNC Alias Symbols

GRF2; Ras-GRF2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006909.3

p.R688S

c.2064G>C

Surrounding Variants

1 paper

NM_006909.3

p.R688S

c.2064G>T

1 paper

NM_006909.3

p.V695L

c.2083G>C

1 paper

NM_006909.3

p.V677A

c.2030T>C

1 paper

NM_006909.3

p.I659T

c.1976T>C

2 papers

NM_006909.3

p.R650*

c.1948C>T

1 paper

NM_006909.3

p.S643R

c.1929C>A

1 paper

NM_006909.3

p.S643R

c.1929C>G

1 paper

NM_006909.3

p.S643R

c.1927A>C

1 paper

NM_006909.3

p.R640H

c.1919G>A

1 paper

NM_006909.3

p.Q638fs

c.1912_1913fs

1 paper

NM_006909.3

p.P637_L647delFs

c.1911_1939del29

1 paper

NM_006909.3

p.K629Q

c.1885A>C