Varaico: Literature-Extracted Genetic Variants

RASGRF2

88 papers

RefSeq Summary

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1,...

Pfam Domains

PHaa 23–133UCSCPH domain

RhoGEFaa 247–427UCSCRhoGEF domain

RasGEF_Naa 638–771UCSCRasGEF N-terminal motif

RasGEFaa 1005–1183UCSCRasGEF domain

Gene Aliases

HGNC Name

Ras protein specific guanine nucleotide releasing factor 2

HGNC Alias Symbols

GRF2; Ras-GRF2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006909.3

p.R743T

c.2228G>C

Surrounding Variants

1 paper

NM_006909.3

p.T748I

c.2243C>T

3 papers

NM_006909.3

p.S753P

c.2257T>C

1 paper

NM_006909.3

p.R723H

c.2168G>A

1 paper

NM_006909.3

p.R720C

c.2158C>T

1 paper

NM_006909.3

p.L713W

c.2138T>G

1 paper

NM_006909.3

p.Q783*

c.2347C>T

1 paper

NM_006909.3

p.R790T

c.2369G>C

1 paper

NM_006909.3

p.D807Y

c.2419G>T

1 paper

NM_006909.3

p.R810C

c.2428C>T

1 paper

NM_006909.3

p.S820S

c.2460T>C

1 paper

NM_006909.3

p.A824S

c.2470G>T

1 paper

NM_006909.3

p.V695L

c.2083G>C