Varaico: Literature-Extracted Genetic Variants

RASGRP3

77 papers

RefSeq Summary

The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and se...

Pfam Domains

RasGEFaa 155–331UCSCRasGEF domain

C1_1aa 495–547UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Gene Aliases

HGNC Name

RAS guanyl releasing protein 3

HGNC Alias Symbols

KIAA0846; GRP3; CalDAG-GEFIII

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001139488.2

p.K8N

c.24A>C

Surrounding Variants

1 paper

NM_001139488.2

p.K8N

c.24A>T

1 paper

NM_001139488.2

p.S4delFs

c.12delT

1 paper

NM_001139488.2

p.S4fs

c.10_11fs

1 paper

NM_001139488.2

p.L15P

c.44T>C

1 paper

NM_001139488.2

p.M1insFs

c.1_2ins25

1 paper

NM_001139488.2

p.M1insFs

c.1_2ins5

1 paper

NM_001139488.2

p.M1ins12

c.1_2ins36

1 paper

NM_001139488.2

p.M1ins14

c.1_2ins42

1 paper

NM_001139488.2

p.M1insFs

c.1_2ins16

1 paper

NM_001139488.2

p.M1insFs

c.1_2ins38

1 paper

NM_001139488.2

p.M1ins3

c.1_2ins9

1 paper

NM_001139488.2

p.C19*

c.57C>A