Varaico: Literature-Extracted Genetic Variants

RASGRP3

77 papers

RefSeq Summary

The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and se...

Pfam Domains

RasGEFaa 155–331UCSCRasGEF domain

C1_1aa 495–547UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Gene Aliases

HGNC Name

RAS guanyl releasing protein 3

HGNC Alias Symbols

KIAA0846; GRP3; CalDAG-GEFIII

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001139488.2

p.D627Y

c.1879G>T

Surrounding Variants

1 paper

NM_001139488.2

p.D627E

c.1881C>A

1 paper

NM_001139488.2

p.D627E

c.1881C>G

1 paper

NM_001139488.2

p.G629E

c.1886G>A

1 paper

NM_001139488.2

p.S630P

c.1888T>C

1 paper

NM_001139488.2

p.M636I

c.1908G>A

1 paper

NM_001139488.2

p.M636I

c.1908G>C

1 paper

NM_001139488.2

p.M636I

c.1908G>T

1 paper

NM_001139488.2

p.D676A

c.2027A>C

1 paper

NM_001139488.2

p.E575Q

c.1723G>C

1 paper

NM_001139488.2

p.E681G

c.2042A>G

1 paper

NM_001139488.2

p.Q685H

c.2055G>C

1 paper

NM_001139488.2

p.Q685H

c.2055G>T