RNA binding fox-1 homolog 1

A2BP1

FOX-1

HRNBP1

RNA binding protein, fox-1 homolog (C. elegans) 1

RNA binding protein, fox-1 homolog 1

ataxin 2-binding protein 1

hexaribonucleotide binding protein 1

RNA binding protein fox-1 homolog 1

Ataxin-2-binding protein 1

Fox-1 homolog A

Hexaribonucleotide-binding protein 1

Calcitonin gene-related peptide regulator C terminal

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Varaico: Literature-Extracted Genetic Variants

RBFOX1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols