replication factor C subunit 1

PO-GA

RFC140

MHCBFB

replication factor C (activator 1) 1 (145kD)

replication factor C (activator 1) 1, 145kDa

Replication factor C subunit 1

Activator 1 140 kDa subunit

Activator 1 large subunit

Activator 1 subunit 1

DNA-binding protein PO-GA

Replication factor C 140 kDa subunit

Replication factor C large subunit

A1 140 kDa subunit

RF-C 140 kDa subunit

ATPase family associated with various cellular activities (AAA)

Replication factor RFC1 C terminal domain

This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011].

Varaico: Literature-Extracted Genetic Variants

RFC1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols