Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.R852C

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_004850.5
p.R852C
c.2554C>T
Surrounding Variants
1 paper
NM_004850.5
p.K850Splc
c.2550-1G>A
2 papers
NM_004850.5
p.D854V
c.2561A>T
1 paper
NM_004850.5
p.E933D
c.2799A>T
1 paper
NM_004850.5
p.E933D
c.2799A>C
1 paper
NM_004850.5
p.K941N
c.2823A>T
1 paper
NM_004850.5
p.K941N
c.2823A>C
1 paper
NM_004850.5
p.E942Q
c.2824G>C
1 paper
NM_004850.5
p.M945L
c.2833A>T
1 paper
NM_004850.5
p.M945L
c.2833A>C
1 paper
NM_004850.5
p.M953I
c.2859G>T
1 paper
NM_004850.5
p.M953I
c.2859G>C
1 paper
NM_004850.5
p.M953I
c.2859G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."