Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.T677fs

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004850.5
p.T677fs
c.2029_2030fs
Surrounding Variants
1 paper
NM_004850.5
p.T677N
c.2030C>A
1 paper
NM_004850.5
p.A663T
c.1987G>A
2 papers
NM_004850.5
p.N622S
c.1865A>G
5 papers
NM_004850.5
p.D601V
c.1802A>T
1 paper
NM_004850.5
p.T584S
c.1751C>G
1 paper
NM_004850.5
p.T584S
c.1750A>T
1 paper
NM_004850.5
p.L581*
c.1742T>G
1 paper
NM_004850.5
p.L581*
c.1742T>A
1 paper
NM_004850.5
p.A579V
c.1736C>T
1 paper
NM_004850.5
p.S575delFs
c.1724_1725delAG
1 paper
NM_004850.5
p.T573I
c.1718C>T
1 paper
NM_004850.5
p.R572delFs
c.1714_1715delCG
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