Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.V533F

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004850.5
p.V533F
c.1597G>T
Surrounding Variants
1 paper
NM_004850.5
p.E514G
c.1541A>G
1 paper
NM_004850.5
p.K511*
c.1531A>T
1 paper
NM_004850.5
p.V533F
c.1597G>T
1 paper
NM_004850.5
p.R491L
c.1472G>T
1 paper
NM_004850.5
p.R491Q
c.1472G>A
1 paper
NM_004850.5
p.R491G
c.1471C>G
1 paper
NM_004850.5
p.Q548E
c.1642C>G
1 paper
NM_004850.5
p.R572fs
c.1714_1715fs
1 paper
NM_004850.5
p.R572delFs
c.1714_1715delCG
1 paper
NM_004850.5
p.T573I
c.1718C>T
1 paper
NM_004850.5
p.S575delFs
c.1724_1725delAG
1 paper
NM_004850.5
p.A579V
c.1736C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."