Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.S457N

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004850.5
p.S457N
c.1370G>A
Surrounding Variants
1 paper
NM_004850.5
p.Q461H
c.1383A>T
1 paper
NM_004850.5
p.C470ins2
c.1409_1410ins6
1 paper
NM_004850.5
p.S472insFs
c.1414_1415ins8
1 paper
NM_004850.5
p.R476ins2
c.1426_1427ins6
1 paper
NM_004850.5
p.L477L
c.1429C>T
1 paper
NM_004850.5
p.E486delFs
c.1456_1457delTC
1 paper
NM_004850.5
p.Q443*
c.1327C>T
1 paper
NM_004850.5
p.S442C
c.1324A>T
1 paper
NM_004850.5
p.R491G
c.1471C>G
1 paper
NM_004850.5
p.R491L
c.1472G>T
1 paper
NM_004850.5
p.R491Q
c.1472G>A
1 paper
NM_004850.5
p.K511*
c.1531A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."