Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.D393N

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004850.5
p.D393N
c.1177G>A
Surrounding Variants
1 paper
NM_004850.5
p.D385G
c.1154A>G
1 paper
NM_004850.5
p.D385N
c.1153G>A
1 paper
NM_004850.5
p.Y416C
c.1247A>G
1 paper
NM_004850.5
p.E418*
c.1252G>T
1 paper
NM_004850.5
p.D362N
c.1084G>A
1 paper
NM_004850.5
p.L420Splc
c.1260-125A>G
2 papers
NM_004850.5
p.T431S
c.1291A>T
2 papers
NM_004850.5
p.T431S
c.1292C>G
28 papers
NM_004850.5
p.T431N
c.1292C>A
1 paper
NM_004850.5
p.S433Y
c.1298C>A
1 paper
NM_004850.5
p.S436*
c.1307C>G
1 paper
NM_004850.5
p.S436*
c.1307C>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."