Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.Y166D

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_004850.5
p.Y166D
c.496T>G
Surrounding Variants
1 paper
NM_004850.5
p.V168A
c.503T>C
1 paper
NM_004850.5
p.K224N
c.672A>T
1 paper
NM_004850.5
p.K224N
c.672A>C
1 paper
NM_004850.5
p.H227D
c.679C>G
1 paper
NM_004850.5
p.E241_T242Splc
c.724-3C>A
1 paper
NM_004850.5
p.P254L
c.761C>T
2 papers
NM_004850.5
p.D255G
c.764A>G
1 paper
NM_004850.5
p.Y285H
c.853T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."