Varaico: Literature-Extracted Genetic Variants

Gene:ROCK2
Variant:p.R131fs

ROCK2

198 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the...

Pfam Domains

Pkinaseaa 92–354UCSCProtein kinase domain
Rho_Bindingaa 978–1046UCSCRho Binding
PH_MRCKaa 1149–1257UCSCMRCK kinase PH domain

Gene Aliases

HGNC Name

Rho associated coiled-coil containing protein kinase 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004850.5
p.R131fs
c.391_392fs
Surrounding Variants
1 paper
NM_004850.5
p.R131I
c.392G>T
1 paper
NM_004850.5
p.R131delFs
c.391delT
1 paper
NM_004850.5
p.F136C
c.407T>G
2 papers
NM_004850.5
p.W138fs
c.412_413fs
2 papers
NM_004850.5
p.W138delFs
c.412delA
1 paper
NM_004850.5
p.E139Q
c.415G>C
1 paper
NM_004850.5
p.Q115H
c.345G>T
1 paper
NM_004850.5
p.Q115H
c.345G>C
1 paper
NM_004850.5
p.P150H
c.449C>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."