Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.D2207E

c.6621C>G

Surrounding Variants

1 paper

NM_001378902.1

p.D2207E

c.6621C>A

3 papers

NM_002944.3

p.D2213N

c.6637G>A

NM_001378902.1

p.D2207N

c.6619G>A

1 paper

NM_001378902.1

p.F2216L

c.6646T>C

1 paper

NM_001378902.1

p.F2216L

c.6648C>G

1 paper

NM_001378902.1

p.F2216L

c.6648C>A

1 paper

NM_001378902.1

p.D2197H

c.6589G>C

3 papers

NM_002944.3

p.K2228Q

c.6682A>C

NM_001378902.1

p.K2222Q

c.6664A>C

3 papers

NM_002944.3

p.S2229C

c.6686C>G

NM_001378902.1

p.S2223C

c.6668C>G

1 paper

NM_001378902.1

p.C2191Y

c.6572G>A

1 paper

NM_001378902.1

p.R2224R

c.6670A>C

1 paper

NM_001378902.1

p.Q2190*

c.6568C>T

1 paper

NM_001378902.1

p.T2189I

c.6566C>T