Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.L1906L

c.5716C>T

Surrounding Variants

1 paper

NM_001378902.1

p.L1906V

c.5716C>G

1 paper

NM_001378902.1

p.L1906insFs

c.5716_5717insT

2 papers

NM_002944.3

p.G1911R

c.5731G>C

NM_001378902.1

p.G1905R

c.5713G>C

1 paper

NM_001378902.1

p.R1904Q

c.5711G>A

1 paper

NM_001378902.1

p.R1904*

c.5710C>T

1 paper

NM_001378902.1

p.E1902G

c.5705A>G

15 papers

NM_001378902.1

p.E1902K

c.5704G>A

1 paper

NM_001378902.1

p.G1911A

c.5732G>C

1 paper

NM_001378902.1

p.L1912Q

c.5735T>A

1 paper

NM_001378902.1

p.A1913D

c.5738C>A

1 paper

NM_001378902.1

p.A1915P

c.5743G>C

3 papers

NM_001378902.1

p.A1915T

c.5743G>A