Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.C1363delFs

c.4087_4088delCA

Surrounding Variants

1 paper

NM_002944.3

p.W1371*

c.4112G>A

1 paper

NM_002944.3

p.W1371*

c.4113G>A

1 paper

NM_001378902.1

p.I1369F

c.4105A>T

1 paper

NM_001378902.1

p.A1357E

c.4070C>A

1 paper

NM_001378902.1

p.A1357P

c.4069G>C

15 papers

NM_001378902.1

p.Q1353P

c.4058A>C

1 paper

NM_001378902.1

p.Y1348S

c.4043A>C

1 paper

NM_002944.3

p.I1342T

c.4025T>C

1 paper

NM_001378902.1

p.G1333R

c.3997G>A

1 paper

NM_001378902.1

p.E1330V

c.3989A>T

1 paper

NM_001378902.1

p.T1327T

c.3981T>A

1 paper

NM_001378902.1

p.N1325S

c.3974A>G