Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.V1255M

c.3763G>A

Surrounding Variants

1 paper

NM_001378902.1

p.E1260Q

c.3778G>C

1 paper

NM_001378902.1

p.D1248N

c.3742G>A

6 papers

NM_001378902.1

p.E1239V

c.3716A>T

1 paper

NM_001378902.1

p.E1239G

c.3716A>G

1 paper

NM_001378902.1

p.E1239*

c.3715G>T

1 paper

NM_001378902.1

p.Y1234F

c.3701A>T

1 paper

NM_001378902.1

p.L1278P

c.3833T>C

1 paper

NM_001378902.1

p.L1278_L1279delFs

c.3834_3835delAA

1 paper

NM_001378902.1

p.I1224delFs

c.3672delA

1 paper

NM_001378902.1

p.V1223A

c.3668T>C

1 paper

NM_001378902.1

p.V1223D

c.3668T>A

1 paper

NM_001378902.1

p.L1217_V1218delFs

c.3649_3653del5