Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_001378902.1

p.T854A

c.2560A>G

Surrounding Variants

1 paper

NM_001378902.1

p.V856A

c.2567T>C

2 papers

NM_001378902.1

p.Q860L

c.2579A>T

1 paper

NM_001378902.1

p.D846G

c.2537A>G

3 papers

NM_001378902.1

p.L839L

c.2517C>A

7 papers

NM_001378902.1

p.L833V

c.2497T>G

2 papers

NM_001378902.1

p.T832delFs

c.2495delG

1 paper

NM_001378902.1

p.K827N

c.2481G>T

1 paper

NM_001378902.1

p.K827N

c.2481G>C

1 paper

NM_001378902.1

p.K827K

c.2481G>A

1 paper

NM_001378902.1

p.K827delFs

c.2480delT

1 paper

NM_001378902.1

p.K827T

c.2480A>C

1 paper

NM_001378902.1

p.K827fs

c.2479_2480fs