Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_001378902.1

p.D790G

c.2369A>G

Surrounding Variants

1 paper

NM_001378902.1

p.S791fs

c.2371_2372fs

1 paper

NM_001378902.1

p.V792F

c.2374G>T

2 papers

NM_002944.3

p.M792I

c.2376G>T

NM_001378902.1

p.M787I

c.2361G>T

2 papers

NM_002944.3

p.M792I

c.2376G>C

NM_001378902.1

p.M787I

c.2361G>C

2 papers

NM_002944.3

p.M792I

c.2376G>A

NM_001378902.1

p.M787I

c.2361G>A

2 papers

NM_002944.3

p.N790S

c.2369A>G

NM_001378902.1

p.N785S

c.2354A>G

1 paper

NM_001378902.1

p.D790_T799Fs

c.2370_2395delinsCFs

1 paper

NM_002944.3

p.T804N

c.2411C>A

1 paper

NM_001378902.1

p.V780_K781ins3

c.2340_2341ins9

1 paper

NM_001378902.1

p.V780ins3

c.2339_2340ins9

1 paper

NM_001378902.1

p.V780L

c.2338G>T

1 paper

NM_001378902.1

p.Y802C

c.2405A>G