Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.V780L

c.2338G>T

Surrounding Variants

1 paper

NM_001378902.1

p.V780ins3

c.2339_2340ins9

1 paper

NM_001378902.1

p.V780_K781ins3

c.2340_2341ins9

2 papers

NM_001378902.1

p.V777L

c.2329G>C

1 paper

NM_001378902.1

p.I776ins1

c.2326_2327insTCT

1 paper

NM_001378902.1

p.I776ins1

c.2326_2327insTAT

1 paper

NM_001378902.1

p.I776ins1

c.2326_2327ins3

1 paper

NM_001378902.1

p.T771_D775ins1

c.2313_2324dup12

2 papers

NM_001378902.1

p.D775ins4

c.2324_2325ins12

2 papers

NM_002944.3

p.N790S

c.2369A>G

NM_001378902.1

p.N785S

c.2354A>G

1 paper

NM_001378902.1

p.T774_D775ins4

c.2322_2323ins12

1 paper

NM_001378902.1

p.H773_T774ins1

c.2319_2320insCAG

1 paper

NM_001378902.1

p.H773ins1

c.2318_2319insACA