Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.G772ins1

c.2314_2315insACC

Surrounding Variants

1 paper

NM_001378902.1

p.T771_G772ins1

c.2313_2314insACC

2 papers

NM_001378902.1

p.H773Y

c.2317C>T

1 paper

NM_001378902.1

p.L770_T771ins1

c.2310_2311insGGT

1 paper

NM_001378902.1

p.L770_T771ins1

c.2310_2311insGGG

1 paper

NM_001378902.1

p.L770_T771ins1

c.2310_2311insGGC

1 paper

NM_001378902.1

p.L770_T771ins2

c.2310_2311ins6

1 paper

NM_001378902.1

p.T771ins3

c.2311_2312ins9

1 paper

NM_001378902.1

p.H773L

c.2318A>T

1 paper

NM_001378902.1

p.H773ins3

c.2317_2318ins9

1 paper

NM_001378902.1

p.H773_T774ins1

c.2319_2320insTAC

1 paper

NM_001378902.1

p.H773_T774ins3

c.2319_2320ins9

1 paper

NM_001378902.1

p.L770ins3

c.2308_2309ins9