Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.A745A

c.2235T>A

Surrounding Variants

1 paper

NM_001378902.1

p.E749Q

c.2245G>C

1 paper

NM_001378902.1

p.A747_E749del0

c.2239_2247del9

4 papers

NM_001378902.1

p.A745_W750del0

c.2235_2249del15

3 papers

NM_001378902.1

p.L746_W750del0

c.2236_2250del15

1 paper

NM_001378902.1

p.L746_L751del0

c.2237_2251del15

1 paper

NM_001378902.1

p.A747_G752del0

c.2240_2254del15

1 paper

NM_001378902.1

p.L746_G752del0

c.2237_2254del18

1 paper

NM_001378902.1

p.A747_H753del0

c.2240_2257del18

3 papers

NM_001378902.1

p.L755P

c.2264T>C

1 paper

NM_001378902.1

p.L755insFs

c.2265dupC

1 paper

NM_001378902.1

p.T729T

c.2187G>A

1 paper

NM_001378902.1

p.V721I

c.2161G>A