Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

22 papers

NM_001378902.1

p.G719S

c.2155G>A

Surrounding Variants

14 papers

NM_001378902.1

p.G719C

c.2155G>T

1 paper

NM_001378902.1

p.G719R

c.2155G>C

24 papers

NM_001378902.1

p.G719A

c.2156G>C

3 papers

NM_001378902.1

p.G719D

c.2156G>A

1 paper

NM_001378902.1

p.D720H

c.2158G>C

1 paper

NM_001378902.1

p.V721I

c.2161G>A

1 paper

NM_001378902.1

p.Y714_S715insT

c.2140_2144ins3

1 paper

NM_001378902.1

p.Y713C

c.2138A>G

1 paper

NM_001378902.1

p.Y713N

c.2137T>A

1 paper

NM_001378902.1

p.N709S

c.2126A>G

1 paper

NM_001378902.1

p.T729T

c.2187G>A

1 paper

NM_001378902.1

p.Y708H

c.2122T>C