Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001378902.1

p.Y391H

c.1171T>C

Surrounding Variants

1 paper

NM_001378902.1

p.Y387*

c.1161T>G

1 paper

NM_001378902.1

p.L397L

c.1189C>T

7 papers

NM_001378902.1

p.S382P

c.1144T>C

3 papers

NM_002944.3

p.S370P

c.1108T>C

NM_001378902.1

p.S379P

c.1135T>C

1 paper

NM_001378902.1

p.L377F

c.1131A>T

1 paper

NM_001378902.1

p.L377F

c.1131A>C

1 paper

NM_001378902.1

p.G376R

c.1126G>C

1 paper

NM_001378902.1

p.G376R

c.1126G>A

1 paper

NM_001378902.1

p.S375S

c.1125A>T

3 papers

NM_001378902.1

p.G374A

c.1121G>C

NM_002944.3

p.G365A

c.1094G>C

1 paper

NM_001378902.1

p.I370M

c.1110T>G

1 paper

NM_001378902.1

p.V365I

c.1093G>A