Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001378902.1

p.P217T

c.649C>A

Surrounding Variants

1 paper

NM_001378902.1

p.S216_P217delins

c.648_649delinsGA

1 paper

NM_002944.3

p.D209N

c.625G>A

1 paper

NM_001378902.1

p.S215fs

c.643_644fs

1 paper

NM_001378902.1

p.S214I

c.641G>T

1 paper

NM_001378902.1

p.V220L

c.658G>C

1 paper

NM_001378902.1

p.E213_S214insT

c.637_641ins3

1 paper

NM_001378902.1

p.E221Q

c.661G>C

1 paper

NM_001378902.1

p.V222I

c.664G>A

1 paper

NM_001378902.1

p.L208S

c.623T>C

1 paper

NM_001378902.1

p.P227_Q228insFs

c.681_682insT

1 paper

NM_001378902.1

p.E204D

c.612A>T

1 paper

NM_001378902.1

p.E204D

c.612A>C