Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001378902.1

p.P190H

c.569C>A

Surrounding Variants

1 paper

NM_001378902.1

p.P190S

c.568C>T

1 paper

NM_001378902.1

p.S192N

c.575G>A

1 paper

NM_001378902.1

p.Y188fs

c.562_563fs

1 paper

NM_001378902.1

p.R196G

c.586A>G

1 paper

NM_001378902.1

p.H198N

c.592C>A

1 paper

NM_001378902.1

p.H200_G201delFs

c.600_601delCA

1 paper

NM_001378902.1

p.V178I

c.532G>A

2 papers

NM_001378902.1

p.R176Q

c.527G>A

1 paper

NM_002944.3

p.R167G

c.499C>G

1 paper

NM_001378902.1

p.H168Q

c.504C>G

1 paper

NM_001378902.1

p.H168Q

c.504C>A

1 paper

NM_001378902.1

p.P166A

c.496C>G