Varaico: Literature-Extracted Genetic Variants

RPA1

391 papers

RefSeq Summary

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important rol...

Pfam Domains

Rep-A_Naa 5–104UCSCReplication factor-A protein 1, N-terminal domain

tRNA_anti-codonaa 197–285UCSCOB-fold nucleic acid binding domain

REPA_OB_2aa 305–402UCSCReplication protein A OB domain

Rep_fac-A_Caa 461–606UCSCReplication factor-A C terminal domain

Gene Aliases

HGNC Name

replication protein A1

HGNC Alias Symbols

REPA1; RPA70; HSSB; RF-A; RP-A

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002945.5

p.E290insFs

c.868_869insT

Surrounding Variants

1 paper

NM_002945.5

p.E290A

c.869A>C

1 paper

NM_002945.5

p.P288L

c.863C>T

1 paper

NM_002945.5

p.P288S

c.862C>T

1 paper

NM_002945.5

p.D292N

c.874G>A

1 paper

NM_002945.5

p.M287I

c.861G>A

1 paper

NM_002945.5

p.M287I

c.861G>C

1 paper

NM_002945.5

p.M287I

c.861G>T

1 paper

NM_002945.5

p.M287T

c.860T>C

4 papers

NM_002945.5

p.V286I

c.856G>A

3 papers

NM_002945.5

p.V286F

c.856G>T

1 paper

NM_002945.5

p.S285F

c.854C>T

1 paper

NM_002945.5

p.N281K

c.843T>A