Varaico: Literature-Extracted Genetic Variants

RPA1

391 papers

RefSeq Summary

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important rol...

Pfam Domains

Rep-A_Naa 5–104UCSCReplication factor-A protein 1, N-terminal domain

tRNA_anti-codonaa 197–285UCSCOB-fold nucleic acid binding domain

REPA_OB_2aa 305–402UCSCReplication protein A OB domain

Rep_fac-A_Caa 461–606UCSCReplication factor-A C terminal domain

Gene Aliases

HGNC Name

replication protein A1

HGNC Alias Symbols

REPA1; RPA70; HSSB; RF-A; RP-A

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002945.5

p.K343N

c.1029G>T

Surrounding Variants

1 paper

NM_002945.5

p.K343N

c.1029G>C

2 papers

NM_002945.5

p.A342V

c.1025C>T

1 paper

NM_002945.5

p.V341D

c.1022T>A

1 paper

NM_002945.5

p.V341I

c.1021G>A

5 papers

NM_002945.5

p.T351A

c.1051A>G

1 paper

NM_002945.5

p.R335R

c.1005G>A

1 paper

NM_002945.5

p.S352C

c.1055C>G

1 paper

NM_002945.5

p.S352F

c.1055C>T

1 paper

NM_002945.5

p.S352S

c.1056C>T

1 paper

NM_002945.5

p.V334A

c.1001T>C

1 paper

NM_002945.5

p.R335Fs

c.1003delinsGAFs

1 paper

NM_002945.5

p.K331*

c.991A>T