Varaico: Literature-Extracted Genetic Variants

RPA1

391 papers

RefSeq Summary

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important rol...

Pfam Domains

Rep-A_Naa 5–104UCSCReplication factor-A protein 1, N-terminal domain

tRNA_anti-codonaa 197–285UCSCOB-fold nucleic acid binding domain

REPA_OB_2aa 305–402UCSCReplication protein A OB domain

Rep_fac-A_Caa 461–606UCSCReplication factor-A C terminal domain

Gene Aliases

HGNC Name

replication protein A1

HGNC Alias Symbols

REPA1; RPA70; HSSB; RF-A; RP-A

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002945.5

p.S384F

c.1151C>T

Surrounding Variants

1 paper

NM_002945.5

p.S384S

c.1152T>C

1 paper

NM_002945.5

p.S384A

c.1150T>G

2 papers

NM_002945.5

p.R382Q

c.1145G>A

1 paper

NM_002945.5

p.F386S

c.1157T>C

2 papers

NM_002945.5

p.G387D

c.1160G>A

1 paper

NM_002945.5

p.G388E

c.1163G>A

1 paper

NM_002945.5

p.G380A

c.1139G>C

1 paper

NM_002945.5

p.G380V

c.1139G>T

5 papers

NM_002945.5

p.R389W

c.1165C>T

1 paper

NM_002945.5

p.K379R

c.1136A>G

1 paper

NM_002945.5

p.R389L

c.1166G>T

1 paper

NM_002945.5

p.V393M

c.1177G>A