Varaico: Literature-Extracted Genetic Variants

RPA1

391 papers

RefSeq Summary

This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important rol...

Pfam Domains

Rep-A_Naa 5–104UCSCReplication factor-A protein 1, N-terminal domain

tRNA_anti-codonaa 197–285UCSCOB-fold nucleic acid binding domain

REPA_OB_2aa 305–402UCSCReplication protein A OB domain

Rep_fac-A_Caa 461–606UCSCReplication factor-A C terminal domain

Gene Aliases

HGNC Name

replication protein A1

HGNC Alias Symbols

REPA1; RPA70; HSSB; RF-A; RP-A

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002945.5

p.G433C

c.1297G>T

Surrounding Variants

1 paper

NM_002945.5

p.G433S

c.1297G>A

1 paper

NM_002945.5

p.G433D

c.1298G>A

5 papers

NM_002945.5

p.G434R

c.1300G>A

5 papers

NM_002945.5

p.G434R

c.1300G>C

1 paper

NM_002945.5

p.G436E

c.1307G>A

2 papers

NM_002945.5

p.G437R

c.1309G>A

1 paper

NM_002945.5

p.D429N

c.1285G>A

2 papers

NM_002945.5

p.G437R

c.1309G>C

1 paper

NM_002945.5

p.G437W

c.1309G>T

1 paper

NM_002945.5

p.S438C

c.1312A>T

1 paper

NM_002945.5

p.S428A

c.1282T>G

1 paper

NM_002945.5

p.D423H

c.1267G>C