receptor like tyrosine kinase

JTK5A

D3S3195

RYK1

JTK5

JTK5A protein tyrosine kinase

RYK receptor-like tyrosine kinase

Tyrosine-protein kinase RYK

Protein tyrosine and serine/threonine kinase

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012].

Varaico: Literature-Extracted Genetic Variants

RYK

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol