Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

1–12 of 1518 variants

113 papers

NM_003000.3

p.R46Q

c.137G>A

102 papers

NM_003000.3

p.R242H

c.725G>A

94 papers

NM_003000.3

p.R90*

c.268C>T

91 papers

NM_003000.3

p.R46*

c.136C>T

77 papers

NM_003000.3

p.S163P

c.487T>C

74 papers

NM_003000.3

p.R230H

c.689G>A

69 papers

NM_003000.3

p.P141_D142Splc

c.423+1G>A

58 papers

NM_003000.3

p.I127S

c.380T>G

54 papers

NM_003000.3

p.C196Y

c.587G>A

53 papers

NM_003000.3

p.V140F

c.418G>T

48 papers

NM_003000.3

p.Q24_A25Splc

c.72+1G>T

47 papers

NM_003000.3

p.R27*

c.79C>T