Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.K255_G256Splc

c.765+4C>T

Surrounding Variants

1 paper

NM_003000.3

p.K255_G256Splc

c.765+4C>A

1 paper

NM_003000.3

p.K255_G256Splc

c.765+5G>T

1 paper

NM_003000.3

p.K255_G256Splc

c.765+5G>A

5 papers

NM_003000.3

p.K255_G256Splc

c.765+1G>A

2 papers

NM_003000.3

p.K255N

c.765G>T

2 papers

NM_003000.3

p.K255N

c.765G>C

1 paper

NM_003000.3

p.K255_G256Splc

c.765+8G>A

1 paper

NM_003000.3

p.T250_P254del5

c.748_761del15

5 papers

NM_003000.3

p.K255*

c.763A>T

5 papers

NM_003000.3

p.K255E

c.763A>G

10 papers

NM_003000.3

p.P254insFs

c.761_762insC

12 papers

NM_003000.3

p.P254L

c.761C>T