Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_003000.3

p.M247V

c.739A>G

Surrounding Variants

2 papers

NM_003000.3

p.M247R

c.740T>G

1 paper

NM_003000.3

p.I246T

c.737T>C

2 papers

NM_003000.3

p.R242_I246del0

c.725_736del12

4 papers

NM_003000.3

p.I246F

c.736A>T

4 papers

NM_003000.3

p.I246V

c.736A>G

1 paper

NM_003000.3

p.R242_T245del0

c.724_735del12

1 paper

NM_003000.3

p.I246_M247del2

c.736_740del6

5 papers

NM_003000.3

p.N248K

c.744C>G

5 papers

NM_003000.3

p.N248K

c.744C>A

4 papers

NM_003000.3

p.C249G

c.745T>G

3 papers

NM_003000.3

p.C249R

c.745T>C

1 paper

NM_003000.3

p.C249S

c.745T>A