Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.R242G

c.724C>G

Surrounding Variants

31 papers

NM_003000.3

p.R242C

c.724C>T

9 papers

NM_003000.3

p.R242S

c.724C>A

102 papers

NM_003000.3

p.R242H

c.725G>A

2 papers

NM_003000.3

p.Y241*

c.723C>G

1 paper

NM_003000.3

p.Y241*

c.723C>A

1 paper

NM_003000.3

p.L240_Y241del1

c.720_722delTAT

5 papers

NM_003000.3

p.E229_R242delFs

c.686_725del40

2 papers

NM_003000.3

p.Y241C

c.722A>G

5 papers

NM_003000.3

p.L240_Y241delFs

c.718_721del4

5 papers

NM_003000.3

p.Y241D

c.721T>G

8 papers

NM_003000.3

p.C243S

c.727T>A

1 paper

NM_003000.3

p.Y241_R242delFs

c.722_726del5