Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.S239Y

c.716C>A

Surrounding Variants

5 papers

NM_003000.3

p.S239F

c.716C>T

4 papers

NM_003000.3

p.S239C

c.716C>G

1 paper

NM_003000.3

p.S239fs

c.715_716fs

1 paper

NM_003000.3

p.S239P

c.715T>C

2 papers

NM_003000.3

p.S239delFs

c.716delG

3 papers

NM_003000.3

p.S239fs

c.715_716fs

1 paper

NM_003000.3

p.F238L

c.714C>G

2 papers

NM_003000.3

p.S239insFs

c.717dupT

6 papers

NM_003000.3

p.F238fs

c.712_713fs

1 paper

NM_003000.3

p.F238L

c.714C>A

11 papers

NM_003000.3

p.F238delFs

c.713delA

1 paper

NM_003000.3

p.S239delFs

c.717delA