Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.D236E

c.708C>G

Surrounding Variants

1 paper

NM_003000.3

p.D236E

c.708C>A

14 papers

NM_003000.3

p.P237S

c.709C>T

1 paper

NM_003000.3

p.P237A

c.709C>G

3 papers

NM_003000.3

p.D236N

c.706G>A

3 papers

NM_003000.3

p.P237R

c.710C>G

1 paper

NM_003000.3

p.Q235H

c.705G>T

1 paper

NM_003000.3

p.P237fs

c.709_710fs

1 paper

NM_003000.3

p.F238L

c.712T>C

1 paper

NM_003000.3

p.F238fs

c.712_713fs

2 papers

NM_003000.3

p.Q235R

c.704A>G

1 paper

NM_003000.3

p.F238S

c.713T>C

2 papers

NM_003000.3

p.Q235*

c.703C>T