Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.L234L

c.700C>T

Surrounding Variants

1 paper

NM_003000.3

p.K233del1

c.697_698delCTT

2 papers

NM_003000.3

p.L234P

c.701T>C

1 paper

NM_003000.3

p.L234Q

c.701T>A

1 paper

NM_003000.3

p.K233_L234delFs

c.697_700del4

1 paper

NM_003000.3

p.K233K

c.699G>A

2 papers

NM_003000.3

p.Q235*

c.703C>T

5 papers

NM_003000.3

p.K233*

c.697A>T

2 papers

NM_003000.3

p.Q235R

c.704A>G

1 paper

NM_003000.3

p.Q235H

c.705G>T

1 paper

NM_003000.3

p.A232V

c.695C>T

3 papers

NM_003000.3

p.D236N

c.706G>A

1 paper

NM_003000.3

p.A232T

c.694G>A