Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.I220V

c.658A>G

Surrounding Variants

1 paper

NM_003000.3

p.I220T

c.659T>C

4 papers

NM_003000.3

p.I220insFs

c.660dupT

2 papers

NM_003000.3

p.D221N

c.661G>A

1 paper

NM_003000.3

p.D221fs

c.661_662fs

2 papers

NM_003000.3

p.W218C

c.654G>T

2 papers

NM_003000.3

p.W218C

c.654G>C

11 papers

NM_003000.3

p.W218*

c.654G>A

2 papers

NM_003000.3

p.D221G

c.662A>G

1 paper

NM_003000.3

p.D221delFs

c.661delC

11 papers

NM_003000.3

p.W218S

c.653G>C

9 papers

NM_003000.3

p.W218*

c.653G>A

1 paper

NM_003000.3

p.W218_M219insA

c.652_656ins3