Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.Q214_A215Splc

c.643-1G>A

Surrounding Variants

3 papers

NM_003000.3

p.A215T

c.643G>A

1 paper

NM_003000.3

p.Q214_A215Splc

c.643-2A>G

1 paper

NM_003000.3

p.Q214_A215Splc

c.643-2A>C

2 papers

NM_003000.3

p.A215V

c.644C>T

1 paper

NM_003000.3

p.A215D

c.644C>A

3 papers

NM_003000.3

p.A215delFs

c.644delG

1 paper

NM_003000.3

p.A215delFs

c.644_645delGG

2 papers

NM_003000.3

p.Y216fs

c.646_647fs

4 papers

NM_003000.3

p.Y216C

c.647A>G

30 papers

NM_003000.3

p.R217C

c.649C>T

5 papers

NM_003000.3

p.R217G

c.649C>G

2 papers

NM_003000.3

p.R217S

c.649C>A