Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.M213delFs

c.639delC

Surrounding Variants

10 papers

NM_003000.3

p.Q214*

c.640C>T

1 paper

NM_003000.3

p.Q214_A215insCT

c.640_644ins6

3 papers

NM_003000.3

p.M213fs

c.637_638fs

3 papers

NM_003000.3

p.Q214R

c.641A>G

1 paper

NM_003000.3

p.Q214P

c.641A>C

6 papers

NM_003000.3

p.M213insFs

c.637dupA

1 paper

NM_003000.3

p.M213T

c.638T>C

16 papers

NM_003000.3

p.Q214H

c.642G>T

18 papers

NM_003000.3

p.Q214H

c.642G>C

2 papers

NM_003000.3

p.Q214Q

c.642G>A

1 paper

NM_003000.3

p.Q214_A215Splc

c.642+1G>T

1 paper

NM_003000.3

p.Q214_A215Splc

c.642+1G>C